Batch Cooling

General Description

Use this operation to simulate a cooling process that takes place in a vessel.

Unit Procedure Availability

      Batch Vessel Procedure in a Reactor

      Batch Vessel Procedure in a Seed Reactor

      Batch Vessel Procedure in a Bioreactor

      Batch Vessel Procedure in a Seed Bioreactor

      Batch Vessel Procedure in a Disposable Bioreactor

      Batch Vessel Procedure in a Disposable Seed Bioreactor

      Batch Vessel Procedure in a Fermentor

      Batch Vessel Procedure in a Seed Fermentor

      Batch Vessel Procedure in a Disposable Bioreactor

      Inoculum Preparation Procedure in a Rocking Bioreactor

      Inoculum Preparation Procedure in a Roller Bottle

      Inoculum Preparation Procedure in a T-Flask

      Inoculum Preparation Procedure in a Shake Flask

      Inoculum Preparation Procedure in a Test Tube

      Nutsche Filtration Procedure

      Freeze Drying Procedure

      Batch Distillation Procedure

      Batch Storage in a Blending Tank Procedure

      Batch Storage in a Flat Bottom Tank Procedure

      Batch Storage in a Receiver Tank Procedure

      Batch Storage in a Horizontal Tank Procedure

      Batch Storage in a Vertical-on-Legs Tank Procedure

      Batch Storage in a Drum Procedure

      Batch Storage in a Drum Procedure

      Batch Storage in a Tote Procedure

      Batch Storage in a Disposable Generic Container Procedure

      Batch Storage in a Disposable Large Bag (on a Skid) Procedure

      Batch 1x1 Generic Box Procedure

      Batch 3x3 Generic Box Procedure

      Batch 5x5 Generic Box Procedure

      Batch 10x10 Generic Box Procedure

Material Inputs / Outputs

The operation uses material as found in the host vessel at the end of the previous operation (if any). The results of the operation are left as the equipment contents at the end of the operation.

Batch Cooling: Modeling Calculations

Several cooling options are available in this model. The cooling time can either be set or calculated. When calculated it can be based on a constant cooling or exponential type where the overall heat transfer coefficient is specified

Cooling Time

In the case of a constant cooling rate (dT/dt), the following equation is used to calculate either the cooling rate or the process time:

BatchCoolingTempDiff.jpg 

eq. (A.2)

where ΔT = T0 - T1 is the temperature difference between the initial and the final states. When the user specifies the constant cooling rate, the above equation is solved for cooling time and vice versa.

If an exponential cooling rate is selected, then the user sets the overall UA (kcal/h-°C) and the process time is calculated by the following equation:

BatchCoolingExponentialTemp.jpg 

eq. (A.3)

where TC is the inlet temperature of the cooling agent, T0, T1 are the initial and final temperatures of the vessel contents and MCp is a collective term representing the sum of the vessel contents and equipment heat capacity (kcal/°C).

Energy Balance

For all cooling options, and if the cooling agent is not ignored, the average cooling duty (Q) or power (P) is calculated using the following equation:

BatchCoolingEB.jpg 

eq. (A.4)

where η is either the cooling efficiency if a cooling agent is selected or the coefficient of performance (COP) if electring cooling is selected. The COP is defined as the ratio of cooling load (negative enthalpy change of material contents) to electricity consumption. Note that the COP corresponding to 1 “ton” of refrigeration (12,000 Btu/h) per unit of horse power is approximately 4.7.

Batch Vessel Operations: Equipment Sizing

In Design Mode of calculation, the user specifies the max. allowable working to vessel volume ratio for this equipment. Also the program sets the working (liquid) volume (Vw) equal to the volume of material that is processed per cycle. The number of cycles per batch is specified through the Procedure Data Dialog: Scheduling Tab (Batch Process). The vessel volume (V) is then calculated using the following equation:

VesselVolume.jpg 

eq. (A.5)

If the calculated vessel volume exceeds its maximum possible value (specified through the Equipment tab of the corresponding equipment’s interface), the program assumes multiple (identical) units operating in parallel with a total vessel volume equal to the calculated.

In Rating Mode, the user specifies the vessel volume and the number of units. The program calculates the working to vessel volume ratio and warns the user if its value is outside of its minimum and maximum limits.

Vacuum Pump Power Consumption

See Vacuum Pump Auxiliary Equipment Calculations.

Batch Cooling: Interface

The interface of this operation has the following tabs:

      Oper. Cond’s, see Batch Cooling: Oper. Conds Tab

      Volumes, see Batch Vessel Operations: Volumes Tab

      Vent/Emissions, see Vessel Operations: Vent/Emissions Tab

      Labor, etc, see Operations Dialog: Labor etc. Tab

      Description, see Operations Dialog: Description Tab

      Batch Sheet, see Operations Dialog: Batch Sheet Tab

      Scheduling, see Operations Dialog: Scheduling Tab