Operating Mode
Batch/Semi-Continuous
Host Equipment
Emissions Port (Vent)
No
Special Input/Output Ports
Yes
An Ultrafiltration (Feed and Bleed) Procedure can be created by selecting the following menu option:
Unit Procedures } Filtration } Ultrafiltration (Feed and Bleed)
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Operating Mode |
Batch/Semi-Continuous |
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Host Equipment |
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Emissions Port (Vent) |
No |
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Special Input/Output Ports |
Yes |
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Feed and bleed (continuous) ultrafiltration is used for removing large MW solutes and particulate components from water and other solvents in plants that require large throughputs (e.g., dairy, beverage, water purification, etc.). In the biotech and food industries, tangential flow ultrafiltration is primarily used for concentrating protein solutions and separating proteins from low molecular weight solutes. In water purification it is used for removing small suspended and colloidal particles. Ultrafiltration membranes are rated based on molecular weight cut-off of spherical proteins that cannot pass through the membrane. Membranes are available with MW cut-off ranging from 2,000 Daltons up to 1,000,000 Daltons.
● Filtrate: the designated output port for the filtrate.
● Concentrate: the designated output port for the concentrate.
The following operation types are currently supported in the context of this unit procedure:
● Concentrate (Feed & Bleed), see Feed & Bleed Concentration (Continuous Membrane Filtration)
● CIP, see Clean-In-Place (CIP)
● Hold, see Holding
● SIP, see Steam-In-Place (SIP)
The following procedures offer a similar functionality:
● Ultrafiltration (Batch) Procedure
● Microfiltration (Feed and Bleed) Procedure
● Reverse Osmosis (Feed and Bleed) Procedure