Operating Mode
Batch/Semi-Continuous
Host Equipment
Emissions Port (Vent)
No
Special Input/Output Ports
Yes
A Microfiltration (Feed and Bleed) Procedure can be created by selecting the following menu option:
Unit Procedures } Filtration } Microfiltration (Feed and Bleed)
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Operating Mode |
Batch/Semi-Continuous |
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Host Equipment |
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Emissions Port (Vent) |
No |
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Special Input/Output Ports |
Yes |
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Feed and bleed (continuous) microfiltration is used for solid-liquid separations (to remove micron-size particles) in plants that require large throughputs (e.g., dairy, bioprocessing, beverage, water purification, etc.). In bioprocessing, microfiltration is commonly used for cell harvesting, cell debris removal, and sterilization of cell culture media. The pore sizes of microfilter membranes usually range from 0.1 to 0.45 microns. Flow parallel to the membrane surface is used to enhance filtrate flux.
● Filtrate: the designated output port for the filtrate.
● Concentrate: the designated output port for the concentrate.
The following operation types are currently supported in the context of this unit procedure:
● Concentrate (Feed & Bleed), see Feed & Bleed Concentration (Continuous Membrane Filtration)
● CIP, see Clean-In-Place (CIP)
● Hold, see Holding
● SIP, see Steam-In-Place (SIP)
The following procedures offer a similar functionality:
● Microfiltration (Batch) Procedure
● Ultrafiltration (Feed and Bleed) Procedure
● Reverse Osmosis (Feed and Bleed) Procedure