Nano mills are used in various industries for thorough homogenization and mixing of suspension mixtures. It is a common processing step in pharmaceutical dosage formulation when the active ingredient (API) is not soluble in water.
In Design Mode of calculation, the user specifies the residence time (tR) and the packing density. The working (liquid) volume (Vw) and the vessel volume (V) are calculated using the following equations:
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where F is the liquid/solid volumetric flowrate of the feed. If the calculated vessel volume exceeds its maximum possible value (specified through the Equipment tab), the program assumes multiple, identical units operating in parallel with a total vessel volume equal to the calculated.
In Rating Mode, the user specifies the vessel volume and the number of units and the program calculates the residence time.
If the flow is recirculated then the ‘effective feed flowrate’, used to calculate the volume in design mode and the residence time in rating mode, is the actual liquid/solid volumetric flowrate of the feed times the recirculation times.
If this unit operates in a batch plant, the liquid/solid volumetric flowrate of the feed is calculated by dividing the liquid/solid volume of material that needs to be processed per cycle by the process time.
The user can either set the overall power or the specific power per volume of equipment. The user also specifies what percentage of the pumping power dissipates into heat (and therefore contributes to the heat exchange agent requirement).
The interface of this operation has the following tabs:
● Oper. Cond’s, see Nano-Milling: Oper. Conds Tab
● Labor, etc, see Operations Dialog: Labor etc. Tab
● Description, see Operations Dialog: Description Tab
● Batch Sheet, see Operations Dialog: Batch Sheet Tab
● Scheduling, see Operations Dialog: Scheduling Tab
