This operation simulates a column regeneration step in ion exchange chromatography which is used to restore the column to its initial state. The main objective of this operation is to estimate the time and volume of solution required for regenerating a column. During regeneration, the entire column contents are removed to the waste stream.
● Ion Exchange Procedure (for Demineralization)
The user has flexibility in specifying any of the following combinations: Washing Time and Flowrate, Time and Volume, or Volume and Flowrate. Further, there is considerable flexibility in specifying the flowrate and volume. Note that these quantities correspond to the solution that is consumed in a single column per cycle.
The wash solution volume is equal to the bed volume of the column times the volume factor (in packed bed volumes) that is specified by the user. Since the flowrate of a wash stream is adjusted by the model, the user must make sure that the composition of the stream is correct and not worry about the total stream flowrate.
When the user specifies the Approach Velocity (also known as Linear Velocity), the process time is calculated using the following equation:
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The feed (wash) volume in the above equation is expressed in ‘packed bed volumes’.
All materials used for washing (regenerating) a column, as well as all bound material to the column, end up in a waste stream.
The interface of this operation has the following tabs:
● Oper. Cond’s, see INX Column Regeneration: Oper. Conds Tab
● Labor, etc, see Operations Dialog: Labor etc. Tab
● Description, see Operations Dialog: Description Tab
● Batch Sheet, see Operations Dialog: Batch Sheet Tab
● Scheduling, see Operations Dialog: Scheduling Tab