Fermentation Operations: Oper. Conds Tab

FermOperConds.jpg

This operating conditions tab is common between stoichiometric, kinetic and perfusion batch fermentation operations. Notice that the Assume No Phase Change(s) in Reactor option is only available in kinetic fermentation operations when the thermal mode is set to Adiabatic or Set Duty.

Variable Definitions, Ranges and Default Values

The following table shows a brief description of the variables appearing in this tab. The table also displays their default values and their generally acceptable range:

Variable

Default Value

Range

 

◙ Final Temperature (oC)
The final temperature of vessel contents after the end of the operation.

37.0

Positive

◙ Heating Duty (kcal/h)
The heat transfer rate of the heating agent, if a heating agent is used.

0.0

Positive

◙ Cooling Duty (kcal/h)
The heat transfer rate of the cooling agent, if a cooling agent is used.

0.0

Positive

○ Heat Transfer Agent Name
Indicates the heat transfer agent used for the operation. Click on the list box to bring up a list of available heat transfer agents in order to select one.

<Chilled Water>

Any Heat Transfer Agent

● Inlet Temp. (oC)
The inlet temperature of the heat transfer agent.

5.0

Positive

● Outlet Temp. (oC)
The outlet temperature of the heat transfer agent.

10.0

Positive

● Rate (kg/h)
The mass flow rate of the heat transfer agent.

0.0

Positive

○ Heat Transfer Efficiency(%)
The heat transfer agent efficiency. If the value is lower than 100% then an increased heat transfer agent amount will be calculated by the program to satisfy the required duty.

100.0

[0,100)

○ Setup Time (min)
The amount of time (per cycle) spent before each operation is carried in preparation for the actual execution of the operation. It may involve actions like cleaning, vacuuming, setting up of equipment, etc. which the user opted not to model explicitly.

0.0

Positive

○ Reaction Time (h)
The actual duration of the operation.

24.0

Positive

○ Ignore Labor?
Check this box to ignore labor for this operation. This option is used only if the process time is set by a master-slave relationship.

Yes

Yes/No

○ Power Type
Indicates the power type that is used by the operation. Click on the list box to bring up a list of available power types in order to select one.

<Std Power>

Any Power Type

◙ Specific Power (Per Volume) (kW/m3)
The power consumed for agitation per volume of material.

3

Positive

◙ Total Power (kW)
The total power consumed for the operation (per cycle).

0.0

Positive

◙ Power Per Unit (kW)
The power consumed for the operation per equipment unit.

0.0

Positive

○ Power Dissipation to Heat (%)
The percentage of total power consumed for this operation that turns into heat, thereby raising the temperature of the material contained in the equipment.

100.0

[0,100]

○ Apply Broth Aeration
Check this box to apply broth aeration.

Yes

Yes/No

○ Air Supply Stream
Indicates the input port that is connected to the air supply stream. If an input stream is already present at the selected port, then the button next to the selection is active. Click on the button to bring up the attached stream’s simulation dialog in order to provide its composition.

<None>

Any Input Port

◙ Broth Aeration Rate (VVM)
The volume of air per volume of liquid and per minute.

0.5

Positive

○ Use Secondary Aeration
Check this box to use a secondary aeration.

No

Yes/No

○ Secondary Air Supply Stream
Indicates the input port that is connected to the secondary air supply stream. If an input stream is already present at the selected port, then the button next to the selection is active. Click on the button to bring up the attached stream’s simulation dialog in order to provide its composition.

<None>

Any Input Port

◙ Secondary Broth Aeration Rate (VVM)
The volume of air per volume of liquid and per minute.

0.0

Positive

○ Assume No Phase Change(s) in Reactor
When this option is checked, the energy balance is done w.r.t the temperature change rate (dT/dt) otherwise, the enthalpy change rate form (dH/dt) is used. Only available in kinetic fementation adiabatic/duty set modes.

Yes

Yes/No

Symbol Key: ○ User-specified value (always input); ● Calculated value (always output); ◙ Sometimes input, sometimes output

Specification Choices / Comments

The following list describes the available specification choices in this tab; for more details on how these are implemented, see Stoichiometric Reaction Operations: Modeling Calculations.

•Process Time Options...

a)     You can set the process time (Reaction Time).

b)  You can match the duration of this operation to the duration of another operation by introducing a master-slave relationship between the two operations. The program will match the setup-time, the process time and the turnaround time of this operation (the ‘slave’) with the corresponding times of the reference operation (the ‘master’ operation). For more on master-slave relationship, see The Scheduling Tab.

•Aeration...

VVM stands for volume of air per volume of liquid per min. When the ‘Set’ option is selected, the program adjusts the flowrate of the Air Supply Stream to correspond to the specified value of VVM. When the ‘Calculate’ option is selected, the program does not adjust the flowrate of the air supply stream. Instead, it simply calculates the VVM that correspond to the specified air flowrate.

•Gaseous Components Available to React Option...

If you don’t check the ‘Gaseous Components Available to React’ option, then only the liquid components will be considered for the reaction.