EBA Chromatography column: Equipment Tab

Variable Definitions, Ranges and Default Values

The following table shows the meaning of the variables appearing in this tab, as well as their default values and their generally acceptable range. Note that due to the manner by which the variables are used by the sizing and costing equations, the range of acceptable values may be further reduced.

Variable	Default Value	Range

Circular Cross Section
○ Height The height of the column.	1.0 m	Positive
◙ Max Diameter The maximum diameter the column may have.	1.2 m	Positive
◙ Diameter The diameter of the column.	0.2 m	Positive
● Volume The volume of the column.	0.0 L	Positive
Square Cross Section
○ Height The height of the column.	1.0 m	Positive
◙ Max Width The maximum width the column maya have.	1.2 m	Positive
◙ Width The width of the column.	0.2 m	Positive
● Volume The volume of the column.	0.0 L	Positive
Sedimented Bed Dimensions
○ Set by User? Set bed dimensions by user.	<Yes>	Yes/No
○ Height The height of the bed.	0.15 m	Positive
○ Min Height The minimum height of the bed.	1.0 m	Positive
● Volume The volume of the bed.	0.0 L	Positive
◙ Overdesign Factor Use a factor greater than 1.0 to design a larger column than that required by the corresponding operation. Used only in design mode.	1.0	Positive

Symbol Key: ○ User-specified value (always input); ● Calculated value (always output); ◙ Sometimes input, sometimes output

Consumables

The EBA Chromatography column requires the use of a consumable. By default the selected consumable is a ‘Dft EBA Chrom Resin’. The user may select the desired consumable for the column from the Chromatography/Adsorption Equipment: Consumables tab.

Sizing: Design Mode

In design mode, the column volume demand is specified by the EBA Chromatography loading operations carried out as part of the (one or more) EBA chromatography unit procedures hosted by the equipment resource. The software will size the column based on the largest demand on column volume amongst all EBA Chrom. loading operations executed in the column. Once the largest column volume demand is determined, it is multiplied by the overdesign factor to determine the total column volume requirement. This is used to calculate the column height and the diameter if the selected column cross section is circular or the width if it is square, based on the specifications for the bed height. If the calculated column diameter or width exceeds the maximum diameter or width specification then the software will assume multiple number of identical units (each with column volume equally distributed) that are operated in parallel.

Sizing: Rating Mode

In User-Defined (Rating Mode), the user specifies the Number of Units, the Column Height, Diameter, the Min. Bed Height, and optionally the Bed Height. If the column is undersized for its separation task, the program displays a warning advising the user to increase the number of cycles per batch or use a larger column.

Costing

The equipment purchase cost is estimated using built-in correlations derived from vendor data. The equipment cost is a function of column dimensions, material of construction, and throughput.

For more information on this equipment, see Expanded Bed Adsorption (EBA) Chromatography Column.

For information on the left-hand side variables and options, see Equipment Data Dialog: Equipment tab.