Batch Concentration: Oper. Conds Tab

Variable Definitions, Ranges and Default Values

The following table shows a brief description of the variables appearing in this tab. The table also displays their default values and their generally acceptable range:

Variable	Default Value	Range

○ Rejection Coefficient (RC) (%) The rejection coefficient of a component.	0.0	0-100
○ Denaturation (%) The percent product denaturation.	5.0	0-100
○ Active Product Indicates the pure component that corresponds to the active product. Click on the list box to bring up a list of available components in order to select one.	<none>	Any Pure Component
○ Denatured Product Indicates the pure component that corresponds to the denatured product. Click on the list box to bring up a list of available components in order to select one.	<none>	Any Pure Component
○ Setup Time The amount of time (per cycle) spent before each operation is carried in preparation for the actual execution of the operation. It may involve actions like cleaning, vacuuming, setting up of equipment, etc. which the user opted not to model explicitly.	0.0	Positive
◙ Filtration Time (min) The actual duration of the operation (per cycle).	240.0	Positive
○ Filtrate Flux (L/m²-h) The actual duration of the operation (per cycle).	20.0	Positive
◙ Concentration Factor The feed to retentate mass ratio.	5.0	Positive
◙ Recovery (%) The permeate to feed mass percentage.	80.0	0-100
◙ Target Concentration (g/L) The desired concentration of a key component after the end of filtration.	300.0	Positive
○ Max Particle Conc. in Retentate (g/L) The maximum allowable particle concentration in the retentate.	600.0	Positive

Symbol Key: ○ User-specified value (always input); ● Calculated value (always output); ◙ Sometimes input, sometimes output

Specification Choices / Comments

The following list describes the available specification choices in this tab; for more details on how these are implemented, see Batch Concentration: Modeling Calculations.

•Filtration Time Options ...

In Rating Mode (specified equipment size), the user has the option of setting either the Filtration Time or the Average Filtrate Flux.

•Product Denaturation...

Product denaturation during membrane filtration is common in bioprocessing. To account for product denaturation, the user must specify the active and denatured forms (must be different components) of the product as well as the denaturation percentage.

•Concentration Specification...

The concentration factor and recovery percentage are two equivalent ways of specifying the extent of filtration (concentration). Concentration Factor is common in bio- and food processing while Recovery is common in water purification applications where the focus is on the amount of water that goes through the membrane. The user has also got the option to specify the desired concentration of a key component at the end of the operation.