Discrete Freeze Drying: Oper. Conds Tab

DFreezeDryingOperConds.jpg
Variable Definitions, Ranges and Default Values

The following table shows a brief description of the variables appearing in this tab. The table also displays their default values and their generally acceptable range:

Variable

Default Value

Range

 

○ Volatile ?
Check the box next to a component to indicate that the corresponding component is volatile.

<No>

Yes/No

◙ Removal (%)
The removal percentage of a volatile component.

0.0

0-100

● Initial LOD (%)
The amount of volatile components in a cake sample measured using a Loss On Drying (LOD) test before cake drying.

0.0

0-100

○ Final LOD (%)
The amount of volatile components in a cake sample measured using a Loss On Drying (LOD) test after cake drying.

5.0

0-100

○ Setup Time
The amount of time (per cycle) spent before each operation is carried in preparation for the actual execution of the operation. It may involve actions like cleaning, vacuuming, setting up of equipment, etc. which the user opted not to model explicitly.

0.0

Positive

● Drying Time (h)
The actual duration of the operation (per cycle).

6.0

Positive

◙ Sublimation Rate (mm/h)
The mass flow rate of solvent components.

100.0

Positive

○ Final Solids Temp. (C)
The temperature of the dried cake.

70.0

Positive

○ Dried Vial Name
The name of the dried vial entities.

<Lyophilized Vial>

Any Text

○ Area per Entity (cm2)
The area of each entity.

20.0

Positive

Symbol Key: ○ User-specified value (always input); ● Calculated value (always output); ◙ Sometimes input, sometimes output

Specification Choices / Comments

The following list describes the available specification choices in this tab; for more details on how these are implemented, see Discrete Freeze Drying: Modeling Calculations.

•Volatile ?...

All volatile components that are removed (evaporate) during drying must be identified as such.

•Volatile Component Evaporation...

If the removal (evaporation) of volatile components is calculated by the program based on Final LOD, all volatile components are removed equally (same removal %). If that is not the case, then, you need to set the removal percentage of the various volatile components.

•Duration Options...

The user has the option to specify either the Drying Time or the Sublimation Rate.

•Dried Vial...

The user specifies a name for the dried entity, and the area that each entity occupies.