Batch Extraction / Phase Split: Mat. Balance Tab (Based on Partition Coefficients)

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Variable Definitions, Ranges and Default Values

The following table shows a brief description of the variables appearing in this tab. The table also displays their default values and their generally acceptable range:

Variable

Default Value

Range

 

○ Partition Coefficients (Ki)
Set this value for available non-solvent components.

0.0

Positive

○ Split %
The percentage of a component that is split to the selected (top or bottom) phase.

0.0

0-100

○ Light Phase Solvent Name
Indicates the component that is used as the light phase solvent in case that a two-solvent system is selected. Click on the list box to bring up a list of available components in order to select one.

<none>

Any Pure Component

○ Solubility in Light Phase (g/L)
The solubility of the heavy phase solvent in the light phase.

0.0

Positive

○ Heavy Phase Solvent Name
Indicates the component that is used as the heavy phase solvent in case that a two-solvent system is selected. Click on the list box to bring up a list of available components in order to select one.

<none>

Any Pure Component

○ Solubility in Heavy Phase (g/L)
The solubility of the light phase solvent in the heavy phase.

0.0

Positive

○ Common Solvent
Indicates the component that is used as solvent in case that a single-solvent system is selected. Click on the list box to bring up a list of available components in order to select one.

<none>

Any Pure Component

○ Fraction in Top (Light) Phase
The fraction of solvent in the light phase in case that a single-solvent system is selected.

0.4

0-1

○ Product Component Name
Indicates the product component. Click on the list box to bring up a list of available components in order to select one.

<none>

Any Pure Component

● Recovery Yield (%)
The product recovery yield.

0.0

0-100

Symbol Key: ○ User-specified value (always input); ● Calculated value (always output); ◙ Sometimes input, sometimes output

Specification Choices / Comments

The following list describes the available specification choices in this tab; for more details on how these are implemented, see Batch Extraction / Phase Split: Modeling Calculations.

•Common solvent systems...

Common solvent systems (e.g., aqueous two-phase systems) are commonly used in biotechnology to recover and purify proteins and other biological molecules.